Carolina Panthers quarterback Cam Newton has been ruled out of Monday night's game against the Tampa Bay Bucs.

Newton, who suffered his first documented concussion in Week Four, remains in the NFL's concussion protocol. It will be just his third missed start since coming into the league in 2011.

"He's antsy," coach Ron Rivera said Saturday. "He can't help himself and that's the part of the thing that you've got to get him to do - calm down, relax, slow down."

As he did twice in 2014, backup Derek Anderson will fill in for Newton against the Bucs. Anderson has a 20-25 career record, but he's 2-0 since coming to Carolina in 2011. In his two wins over Tampa Bay, he went a combined 49-of-74 for 507 yards with three touchdowns and no interceptions.

Other Panthers who are out for Monday night: Left tackle Michael Oher (concussion), cornerback James Bradberry (turf toe), running back Jonathan Stewart (hamstring) and defensive tackle Vernon Butler (high-ankle sprain).

Linebacker Thomas Davis (hamstring), defensive end Charles Johnson (quad), fullback Mike Tolbert (hamstring), receivers Devin Funchess (toe) and Ted Ginn Jr. (foot) are all listed as questionable, but Rivera said he feels "good" about their chances to play.